ABSTRACT
Objective To explore the relationship between the serum PGⅠ,PGⅡ,PGⅠ/PGⅡ ratio(PGR),IgG anti-HP and gastric cancer and the diagnostic value.Methods The levels of serum PGⅠ,PGⅡ,PGⅠ/PGⅡ ratio(PGR) and IgG anti-HP were detected by emulsio immunoturbidimetry and ELISA in 30 patients with gastric cancer and 30 healthy subjects as controls.Then, the best cut-off value was established to screen gastric cancer.Results The levels of serum PGⅠ,PGⅡ,PGR and IgG anti-HP in the gastric cancer group were (33.72±6.49)ng/L, (8.36±1.26)ng/L, (3.67±0.72), (69.74±15.86)IU,respectively,which in the control group were (111.36±15.86)ng/L, (10.57±1.71)ng/L, (10.53±1.34), (34.62±8.94)IU,respectively.The levels of serum PGⅠ,PGⅡ and PGR in the gastric cancer group were significantly lower than those in the control group(t=25.58,5.60,24.67,all P<0.01),while the level of serum IgG anti-HP was significantly higher than that in the control group(t=10.55,P<0.01).Compare the serum PGⅠ, PGR between IgG anti-HP positive group and IgG anti-HP negative group, there was statistically significant differences(t=5.77,4.02,3.76,all P<0.01).According to the ROC curves, the best cut-off points of PGⅠ, PGⅡ, PGR, IgG anti-HP were 32.54 ng/L[sensitivity 80.7%,specificity 75.0%,area under curve (0.775±0.075)], 7.73 ng/L[sensitivity 75.4%,specificity 70.5%,area under curve (0.742±0.071)],3.48[sensitivity 86.4%,specificity 72.5%,area under curve (0.859±0.067)] and 69.11 IU[sensitivity 59.1%,specificity 75.0%,area under curve (0.667±0.089)].Conclusion Detection of serum PGⅠ, PGR, and IgG anti-HP levels can be useful as a way to screen gastric cancer, the PGR may the best single measure to diagnosis of gastric cancer.